Diazepam-induced feeding in captive gray wolves (Canis lupus)

Publication Type:Journal Article
Year of Publication:1991
Authors:Kreeger, TJ, Levine, AS, Seal, US, Callahan, M, Beckel, M
Journal:Pharmacology Biochemistry and Behavior
Volume:39
Date Published:1991
Keywords:Canis lupus
Abstract:

Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p < 0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, ?-CCP (p = 0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, ?-CCE (p = 0.85), decreased the diazepam-indued hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ¨± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

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