Publication Type: | Journal Article |
Year of Publication: | 1986 |
Authors: | Howard, CF, Kessler, MJ, Schwartz, S |
Journal: | American Journal of Primatology |
Volume: | 11 |
Pagination: | 147-162 |
Date Published: | 1986 |
ISBN Number: | 1098-2345 |
Keywords: | Macaca mulatta |
Abstract: | 10.1002/ajp.1350110207.abs Rhesus macaques (Macaca mulatta) from Cayo Santiago were examined for evidence of carbohydrate intolerance indicative of potential development of non-insulin-dependent diabetes mellitus (NIDDM). Monkeys 6 to >20 years from natal Groups J, M, and P, an AGED Group (all >20 years), and unrelated monkeys removed from the island in association with other groups (CAYO), were examined with intravenous glucose tolerance tests (iv-GTT). Morphometric measurements were made on all tested monkeys. Impairments included fasting hyperglycemia (>115 mg/dl), impaired glucose clearance (K <2.0%/min), fasting hyperinsulinemia (>150 μU/ml) or hypoinsulinemia (<20 μU/ml), and insulin secretory abnormalities (>500 μU/ml or <75 μU/ml). Natal groups J and M had 31% with impairments, group P had 0% the AGED group had 45%, and the CAYO group had 33%. Impaired glucose clearance was usually attributable to a reduced insulin response. Impairments correlated significantly (p ⩽ 0.05) to body weight and a modified Quetelet index, but not to sex, acute stress, or islet cell antibodies; the relationships to age could not be delineated in this survey. Impairements in monkeys are indicative of various stages in the asynchronous development of carbohydrate intolerance leading to NIDDM. |
URL: | http://dx.doi.org/10.1002/ajp.1350110207 |
Carbohydrate impairment and insulin secretory abnormalities among Macaca mulatta from Cayo Santiago
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